For educational purposes only — not medical or nutritional advice. Consult a healthcare provider before any extended fast.
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Common questions about fasting
What is the metabolic valley and why does it happen?
Does black coffee break a fast?
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When does autophagy start during fasting?
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Sources & research
FastingPhases is a neutral educational reference. All phase timings and physiological claims above trace to the peer-reviewed studies below. Where the science is uncertain (notably autophagy timing in humans), the chart marks those phases with hatched bars and "emerging evidence" labels rather than false precision.
- Vasim I, Majeed CN, DeBoer MD. "Critical Assessment of Fasting to Promote Metabolic Health and Longevity." Endocrine Reviews, 2025;46(6):856. academic.oup.com
- Ho KY, Veldhuis JD, Johnson ML, et al. "Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man." Journal of Clinical Investigation, 1988;81(4):968–975. jci.org
- Vinales K, et al. "Effects of Short-term Fasting on Ghrelin/GH/IGF-1 Axis in Healthy Humans." 2022. 24-hour fasting induced ~5-fold GH increase (p < 0.001). PMC9387714
- Hartman ML, Veldhuis JD, Johnson ML, et al. "Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men." Journal of Clinical Endocrinology & Metabolism, 1992;74(4):757–765.
- Cahill GF Jr. "Fuel metabolism in starvation." Annual Review of Nutrition, 2006;26:1–22.
- Bagherniya M, et al. "The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting." PMC, 2023. PMC10509423
- Mizushima N, Komatsu M. "Autophagy: renovation of cells and tissues." Cell, 2011;147(4):728–741.
- Cheng CW, Adams GB, Perin L, et al. "Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression." Cell Stem Cell, 2014;14(6):810–823.
- Longo VD, Mattson MP. "Fasting: molecular mechanisms and clinical applications." Cell Metabolism, 2014;19(2):181–192.
- Klein S, Sakurai Y, Romijn JA, Carroll RM. "Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men." Metabolism, 1993.
Framework references: Jason Fung MD, The Complete Guide to Fasting; Thomas DeLauer, Intermittent Fasting Made Easy; Dominic D'Agostino PhD, KetoNutrition. These authors popularize fasting science for general audiences. Primary research citations above take precedence on any factual claim.
FastingPhases is not affiliated with any of the researchers or authors cited. All information is for educational purposes only and is not medical advice. Consult a licensed healthcare provider before any extended fast, especially if you are pregnant, breastfeeding, taking medication, or have a history of eating disorders or metabolic conditions.